Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : CRN04894
CAS No.: 2392970-97-5
Catalog No.: PC-38702Not For Human Use, Lab Use Only.
CRN04894 is a highly potent, selective, orally available melanocortin 2 receptor (MC2R antagonist) antagonist with Ki of 2.1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $388 | In stock | |
| 10 mg | $598 | In stock | |
| 25 mg | Get quote | ||
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
CRN04894 is a highly potent, selective, orally available melanocortin 2 receptor (MC2R antagonist) antagonist with Ki of 2.1 nM.
CRN04894 selectively blocks the ACTH-MC2R interaction, showing no binding to MC1R, MC3R, MC4R, and MC5R at concentrations >1 uM.
CRN04894 demonstrates remarkable efficacy in a rat model of adrenocorticotrophic hormone (ACTH)-stimulated corticosterone secretion.
Oral administration of CRN04894 suppressed ACTH-stimulated corticosterone secretion in a dose-dependent manner at doses ≥3 mg/kg.
| M.Wt | 613.73 | |
| Formula | C33H42F3N5O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
6-(2-ethoxyphenyl)-3-((R)-2-ethyl-4-(1-(trifluoromethyl)cyclobutane-1-carbonyl)piperazin-1-yl)-N-((S)-quinuclidin-3-yl)picolinamide |
|
1. Kim SH, et al. ACS Med Chem Lett. 2024 Mar 19;15(4):478-485.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
