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CRT0105446

Chemical Structure : CRT0105446

CAS No.: 1661846-05-4

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CRT0105446 (CRT-0105446, CRT 0105446)

Catalog No.: PC-70100Not For Human Use, Lab Use Only.

CRT0105446 (CRT-0105446) is a novel potent LIMK inhibitor with IC50 of 8 nM and 32 nM for LIMK1 and LIMK2, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CRT0105446 (CRT-0105446) is a novel potent LIMK inhibitor with IC50 of 8 nM and 32 nM for LIMK1 and LIMK2, respectively.
    CRT0105446 inhibits cofilin phosphorylation and increase αTubulin acetylation in cells.
    CRT0105446 shows significant sensitivity against 656 cancer cell lines, and rhabdomyosarcoma, neuroblastoma and kidney cancer cells (mean EC50=238 uM);

    Physicochemical Properties

    M.Wt 421.438
    Formula C20H18F3N3O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(5-(3-(4-methoxy-2-(trifluoromethyl)phenyl)pyridin-4-yl)thiazol-2-yl)isobutyramide

    References

    1. Mardilovich K, et al. Oncotarget. 2015 Nov 17;6(36):38469-86.

    2. Charles MD, et al. J Med Chem. 2015 Oct 22;58(20):8309-13.

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