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CRT0105950

Chemical Structure : CRT0105950

CAS No.: 1661845-86-8

CRT0105950 (CRT-0105950, CRT 0105950)

Catalog No.: PC-70101Not For Human Use, Lab Use Only.

CRT0105950 (CRT 0105950) is a novel potent LIMK inhibitor with IC50 of 0.3 nM and 1 nM for LIMK1 and LIMK2, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CRT0105950 (CRT 0105950) is a novel potent LIMK inhibitor with IC50 of 0.3 nM and 1 nM for LIMK1 and LIMK2, respectively.
CRT0105950 inhibits cofilin phosphorylation and increase αTubulin acetylation in cells.
CRT0105950 shows significant sensitivity against 656 cancer cell lines, and rhabdomyosarcoma, neuroblastoma and kidney cancer cells (mean EC50=19.2 uM).

Physicochemical Properties

M.Wt 393.889
Formula C21H16ClN3OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-((5-(3-(2-chloro-4-methylphenyl)pyridin-4-yl)thiazol-2-yl)amino)phenol

References

1. Mardilovich K, et al. Oncotarget. 2015 Nov 17;6(36):38469-86.

2. Charles MD, et al. J Med Chem. 2015 Oct 22;58(20):8309-13.

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