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CRT0273750

Chemical Structure : CRT0273750

CAS No.: 1979939-16-6

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CRT0273750 (CRT750, IOA-289)

Catalog No.: PC-38008Not For Human Use, Lab Use Only.

CRT0273750 (IOA-289) is a potent, seletive inhibitor of autotaxin with IC50 of 1 nM.

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5 mg $98 In stock
10 mg $148 In stock
25 mg $258 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CRT0273750 (IOA-289) is a potent, seletive inhibitor of autotaxin with IC50 of 1 nM.
CRT0273750 (IOA-289) does not bind to the catalytic zinc region of ATX but binds to both the substrate pocket as well as to the LPA carrier channel thereby blocking both functions of ATX.
CRT0273750 modulates LPA levels in plasma and is suitable for in vivo studies.

Physicochemical Properties

M.Wt 502.922
Formula C25H22ClF3N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-N-(1-(4-chlorophenyl)ethyl)-3-(3-(4-(trifluoromethoxy)benzyl)-3H-imidazo[4,5-b]pyridin-2-yl)propanamide

References

1. Pritom Shah, et al. Bioorg Med Chem Lett. 2016 Nov 15;26(22):5403-5410.

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