Catalog No.: PC-72808Not For Human Use, Lab Use Only.
CSNK2A inhibitor 2 (CK2 inhibitor Compound 2) is a potent, selective, cell active ATP-competitive inhibitor of host protein kinase Casein Kinase 2 (CSNK2A1/2, pIC50=8.5-8.6), inhibits the pathogenic β-coronaviruses including SARS-CoV-2 (MHV pIC50=8.6)
CSNK2A inhibitor 2 (CK2 inhibitor Compound 2) is a potent, selective, cell active ATP-competitive inhibitor of host protein kinase Casein Kinase 2 (CSNK2A1/2, pIC50=8.5-8.6), inhibits the pathogenic β-coronaviruses including SARS-CoV-2 (MHV pIC50=8.6).
Treatment of the HEK293T-ACE2 cells with 1 μM of the CSNK2A chemical probe SGC-CK2-1 or CSNK2A inhibitor 2 resulted in a 70–80% decrease in spike protein uptake.
Chemical probe CSNK2A inhibitor 2 showed inhibition of virus replication at nanomolar doses where it has remarkably high kinase selectivity.
CSNK2A inhibitor 2 inhibits MHV-nLuc replication in DBT cells with IC50 of <10 nM.
