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CSNK2A inhibitor 2

Chemical Structure : CSNK2A inhibitor 2

CAS No.: 2470424-33-8

CSNK2A inhibitor 2 (CK2 inhibitor Compound 2)

Catalog No.: PC-72808Not For Human Use, Lab Use Only.

CSNK2A inhibitor 2 (CK2 inhibitor Compound 2) is a potent, selective, cell active ATP-competitive inhibitor of host protein kinase Casein Kinase 2 (CSNK2A1/2, pIC50=8.5-8.6), inhibits the pathogenic β-coronaviruses including SARS-CoV-2 (MHV pIC50=8.6)

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CSNK2A inhibitor 2 (CK2 inhibitor Compound 2) is a potent, selective, cell active ATP-competitive inhibitor of host protein kinase Casein Kinase 2 (CSNK2A1/2, pIC50=8.5-8.6), inhibits the pathogenic β-coronaviruses including SARS-CoV-2 (MHV pIC50=8.6).
Treatment of the HEK293T-ACE2 cells with 1 μM of the CSNK2A chemical probe SGC-CK2-1 or CSNK2A inhibitor 2 resulted in a 70–80% decrease in spike protein uptake.
Chemical probe CSNK2A inhibitor 2 showed inhibition of virus replication at nanomolar doses where it has remarkably high kinase selectivity.
CSNK2A inhibitor 2 inhibits MHV-nLuc replication in DBT cells with IC50 of <10 nM.

Physicochemical Properties

M.Wt 433.52
Formula C22H27N9O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

Chemical Name/SMILES

References

1. Carrow I Wells, et al. Cell Chem Biol. 2021 Apr 15;28(4):546-558.e10.

2. Xuan Yang, et al. bioRxiv. 2022 Jan 4;2022.01.03.474779.

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