CTL4 inhibitor DT-13

Chemical Structure : CTL4 inhibitor DT-13

CAS No.: 87480-46-4

Catalog No.: PC-27125Not For Human Use, Lab Use Only.

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Biological Activity

CTL4 inhibitor DT-13 is a potent small molecule choline transporter-like protein 4 (CTL4) inhibitor with IC50 of 12.47 uM, directly binds to CTL4 with MST Kd of 0.64 uM, inhibits CTL4-mediated choline uptake.
DT-13 reduces choline and sphingomyelin (SM) levels in UWB1.289 cells in a dose-dependent manner.
DT-13 exhibis significantly great anti-invasive potency in BRCA1-KO KGN cells.
DT-13 significantly reduces the number of liver and gut metastatic nodules originating from BRCA1 KO orthotopic tumors in orthotopic and metastatic cancer model using BRCA1-KO KGN cells.

Physicochemical Properties

M.Wt	855.03
Formula	C44H70O16
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-2-(((4S,5'S,6aR,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)oxy)-4-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol

References

1. Wang C, et al. Nat Commun. 2026 Jun 20. doi: 10.1038/s41467-026-74652-2.