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CTPI-2

Chemical Structure : CTPI-2

CAS No.: 68003-38-3

CTPI-2 (SLC25A1 inhibitor CTPI-2)

Catalog No.: PC-35588Not For Human Use, Lab Use Only.

CTPI-2 (SLC25A1 inhibitor CTPI-2) is a novel specific SLC25A1 inhibitor with Kd of 3.5 uM, CTPI-2 is synthetic lethal with cisplatin or with EGFR inhibitor co-treatment and restores antitumor responses both in vitro and in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CTPI-2 (SLC25A1 inhibitor CTPI-2) is a novel specific SLC25A1 inhibitor with Kd of 3.5 uM, CTPI-2 is synthetic lethal with cisplatin or with EGFR inhibitor co-treatment and restores antitumor responses both in vitro and in vivo.
CTPI-2 disrupts self-renewal and sphere-forming capacity of the indicated tumor cells relative to monolayer cultures, demonstrates broad activity on lung CSCs, inhibiting mitochondrial respiratory activity, self-renewal and matrix invasion.
CTPI-2 inhibits tumor growth in in vivo models of NSCLC.

Physicochemical Properties

M.Wt 356.733
Formula C13H9ClN2O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-((4-chloro-3-nitrophenyl)sulfonamido)benzoic acid

References

1. Fernandez HR, et al. Cell Death Differ. 2018 Jul;25(7):1239-1258.

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