Chemical Structure : CTX-712
CAS No.: 2144751-78-8
Catalog No.: PC-21434Not For Human Use, Lab Use Only.
Rogocekib (CTX-712) is an orally available and highly potent cdc2-like kinase (CLK) inhibitor with IC50 of 1.4 nM (CLK2).
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Rogocekib (CTX-712) is an orally available and highly potent cdc2-like kinase (CLK) inhibitor with IC50 of 1.4 nM (CLK2).
CTX-712 strongly inhibits phosphorylation of multiple SR proteins including SRSF3, SRSF4, SRSF5, and SRSF6 that bind to SRSF2.
CTX-712 exhibits anti-leukemic activities both in vitro and in vivo, targeting myeloid neoplasms with SRSF2 mutation.
M.Wt | 408.40 | |
Formula | C19H17FN8O2 | |
Appearance | Solid | |
Storage |
|
|
Solubility |
10 mM in DMSO |
|
Chemical Name/SMILES |
(R)-2-(1-fluoroethyl)-5-((6-(4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-methyl-1H-imidazo[4,5-b]pyridin-1-yl)methyl)-1,3,4-oxadiazole |
1. Akinori Yoda PhD, et al. Blood. Volume 134, Supplement 1, 13 November 2019, Page 404
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright