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CTX-712

Chemical Structure : CTX-712

CAS No.: 2144751-78-8

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CTX-712 (CTX712)

Catalog No.: PC-21434Not For Human Use, Lab Use Only.

CTX-712 is an orally available and highly potent cdc2-like kinase (CLK) inhibitor with IC50 of 1.4 nM (CLK2).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CTX-712 is an orally available and highly potent cdc2-like kinase (CLK) inhibitor with IC50 of 1.4 nM (CLK2).
CTX-712 strongly inhibits phosphorylation of multiple SR proteins including SRSF3, SRSF4, SRSF5, and SRSF6 that bind to SRSF2.
CTX-712 exhibits anti-leukemic activities both in vitro and in vivo, targeting myeloid neoplasms with SRSF2 mutation.

Physicochemical Properties

M.Wt 408.40
Formula C19H17FN8O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-2-(1-fluoroethyl)-5-((6-(4-methoxypyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-methyl-1H-imidazo[4,5-b]pyridin-1-yl)methyl)-1,3,4-oxadiazole

References

1. Akinori Yoda PhD, et al. Blood. Volume 134, Supplement 1, 13 November 2019, Page 404

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