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CU-76

Chemical Structure : CU-76

CAS No.: 2400954-58-5

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CU-76 (cGAS inhibitor CU-76)

Catalog No.: PC-73123Not For Human Use, Lab Use Only.

CU-76 (cGAS inhibitor CU-76) is a small-molecule human cGAS (hcGAS) inhibitor with IC50 of 0.24 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CU-76 (cGAS inhibitor CU-76) is a small-molecule human cGAS (hcGAS) inhibitor with IC50 of 0.24 uM.
    CU-76 selectively inhibit the DNA pathway in human cells but have no effect on the RIG-I-MAVS or Toll-like receptor pathways.
    CU-76 represents a new class of hcGAS inhibitor with activity in cells and chemical scaffold for designing probes to study cGAS function and development of autoimmune therapeutics.

    Physicochemical Properties

    M.Wt 407.119
    Formula C11H8F2IN5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Methyl 4-amino-6-((3,5-difluoro-4-iodophenyl)amino)-1,3,5-triazine-2-carboxylate

    References

    1. Padilla-Salinas R, et al. J Org Chem. 2019 Dec 12. doi: 10.1021/acs.joc.9b02666.

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