CU239 | RPE65 inhibitor | Probechem Biochemicals

Chemical Structure : CU239

CU239 (CU 239, CU-239)

Catalog No.: PC-63457Not For Human Use, Lab Use Only.

CU239 is a novel non-retinoid RPE65 inhibitor that selectively inhibits isomerase activity of RPE65 with IC50 of 6 uM.

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Biological Activity

CU239 is a novel non-retinoid RPE65 inhibitor that selectively inhibits isomerase activity of RPE65 with IC50 of 6 uM.
CU239 inhibits RPE65 via competition with its substrate all-trans-retinyl ester.
CU239 suppresses visual cycle and prevents retinal degeneration in mice.

Physicochemical Properties

M.Wt	436.409
Formula	C19H15F3N4O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-(3-phenylureido)thiazol-4-yl)-N-(4-(trifluoromethoxy)phenyl)acetamide

References

1. Shin Y, et al. Biochim Biophys Acta. 2018 Apr 21. pii: S0925-4439(18)30146-7.

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CU239 (CU 239, CU-239)

Biological Activity

Physicochemical Properties

References

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