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CVM-2-12-2

Chemical Structure : CVM-2-12-2

CAS No.: 1628758-48-4

CVM-2-12-2 (DENV E protein inhibitor)

Catalog No.: PC-22506Not For Human Use, Lab Use Only.

CVM-2-12-2 is a selective and potent inhibitor of the envelope (E) protein of dengue virus (DENV), demonstrates potent antiviral activity.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CVM-2-12-2 is a selective and potent inhibitor of the envelope (E) protein of dengue virus (DENV), demonstrates potent antiviral activity.
CVM-2-12-2 engages Thr48, with a binding pose similar to that of GNF-2, while forming a key hydrogen-bonding interaction with Gln271.
CVM-2-12-2 caused a reduction of E at 5 and 10 μM concentrations due the antiviral activity it exerts on E-mediated fusion during viral entry.

Physicochemical Properties

M.Wt 430.31
Formula C18H12F6N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N2-(2-(trifluoromethoxy)phenyl)-N4-(4-(trifluoromethoxy)phenyl)pyrimidine-2,4-diamine

References

1. Li Z, et al. bioRxiv [Preprint]. 2024 Jun 2:2024.06.01.596987.

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