Chemical Structure : CVM-2-12-2
Catalog No.: PC-22506Not For Human Use, Lab Use Only.
CVM-2-12-2 is a selective and potent inhibitor of the envelope (E) protein of dengue virus (DENV), demonstrates potent antiviral activity.
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CVM-2-12-2 is a selective and potent inhibitor of the envelope (E) protein of dengue virus (DENV), demonstrates potent antiviral activity.
CVM-2-12-2 engages Thr48, with a binding pose similar to that of GNF-2, while forming a key hydrogen-bonding interaction with Gln271.
CVM-2-12-2 caused a reduction of E at 5 and 10 μM concentrations due the antiviral activity it exerts on E-mediated fusion during viral entry.
M.Wt | 430.31 | |
Formula | C18H12F6N4O2 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Li Z, et al. bioRxiv [Preprint]. 2024 Jun 2:2024.06.01.596987.
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