Catalog No.: PC-61349Not For Human Use, Lab Use Only.
CVT-10216 (GS-455534) is a potent, highly selective, reversible inhibitor of ALDH2 with IC50 of 29 nM, shows no significant inhibition for ALDH1 (IC50=1,300 nM).
CVT-10216 (GS-455534) is a potent, highly selective, reversible inhibitor of ALDH2 with IC50 of 29 nM, shows no significant inhibition for ALDH1 (IC50=1,300 nM).
CVT-10216 demonstrates therapeutic potential to reduce excessive drinking and to suppress relapse in abstinent alcoholics.
CVT-10216 also shows both anxiolytic and antidipsotropic properties in rats.
CVT-10216 selectively suppresses binge eating of palatable food and attenuates dopamine release in the accumbens of sugar-bingeing rats.
