CVT-313 (CVT313) is a potent, specific CDK2 inhibitor with IC50 of 0.5 uM (CDK2/cyclin A), equally inhibits CDK2/cyclin E. CVT-313 displays 8.5-fold and 430-fold selectivity over CDK1 and CDK4, 2500-fold over mitogen-activated protein kinase and protein kinase A, and PKC. CVT-313 inhibits cell proliferation at the G1/S or G2/M boundary (Caco-2 cell, IC50=4.5 uM). CVT-313 inhibits Rb phosphorylation, inhibits neointima formation in rat carotid artery model of restenosis.
