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CVT-6694

Chemical Structure : CVT-6694

CAS No.: 531506-57-7

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CVT-6694 (CVT6694)

Catalog No.: PC-22013Not For Human Use, Lab Use Only.

CVT-6694 (CVT6694) is a highly potent, selective A2B adenosine receptor antagonist with Ki of 7 nM (hA2B), >700-fold selective over human A1, A2A and A3 receptors.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CVT-6694 (CVT6694) is a highly potent, selective A2B adenosine receptor antagonist with Ki of 7 nM (hA2B), >700-fold selective over human A1, A2A and A3 receptors.
CVT-6694 blocks the release of interleukin-6 and monocyte chemotactic protein-1 from bronchial smooth muscle cells (BSMC).
CVT-6694 inhibits the release of IL-6 and the differentiation of fibroblasts into myofibroblasts in human lung fibroblasts (HLFs).

Physicochemical Properties

M.Wt 452.86
Formula C20H17ClN8O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

8-(1-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1-propyl-3,7-dihydro-1H-purine-2,6-dione

References

1. Rao V Kalla, et al. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1397-401.

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