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Chemical Structure : CWHM-117
Catalog No.: PC-49831Not For Human Use, Lab Use Only.
CWHM-117 is potent nanomolar inhibitor of the Plasmodium aspartic proteases PM-II and PM-IV with IC50 of 4 and 15 nM respectively, exhibits IC50 of 463 nM in the Pf 3D7 infected RBC assays.
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CWHM-117 is potent nanomolar inhibitor of the Plasmodium aspartic proteases PM-II and PM-IV with IC50 of 4 and 15 nM respectively, exhibits IC50 of 463 nM in the Pf 3D7 infected RBC assays.
CWHM-117 is >1000-fold selective for PM-II over BACE and CatD and 300-fold over CatE.
CWHM-117 exhibits potent antimalarial potency while reducing inhibition of human aspartic proteases such as BACE.
| M.Wt | 393.49 | |
| Formula | C23H27N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Marvin J Meyers, et al. ACS Med Chem Lett. 2013 Dec 6;5(1):89-93.
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