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CWP-232228

Chemical Structure : CWP-232228

CAS No.: 1144044-02-9

CWP-232228 (CWP232228)

Catalog No.: PC-61809Not For Human Use, Lab Use Only.

CWP-232228 is a highly potent small-molecule Wnt/β-catenin signaling inhibitor that targets the β-catenin/Tcf4 interaction in the nucleus.

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Biological Activity

CWP-232228 is a highly potent small-molecule Wnt/β-catenin signaling inhibitor that targets the β-catenin/Tcf4 interaction in the nucleus.
CWP-232228 preferentially inhibits the growth of breast cancer stem cells (BCSC) as well as bulk tumor cells.
CWP-232228 inhibits β-catenin-mediated transcription and attenuates IGF-I-mediated BCSC functions.
CWP-232228 reduces tumor growth in a murine xenograft model.

Physicochemical Properties

M.Wt 717.63
Formula C33H34N7Na2O7P
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Sodium 4-(((6S,9aS)-2-allyl-1-(benzylcarbamoyl)-8-((2-methyl-2H-indazol-7-yl)methyl)-4,7-dioxooctahydro-1H-pyrazino[2,1-c][1,2,4]triazin-6-yl)methyl)phenyl phosphate

References

1. Jang GB, et al. Cancer Res. 2015 Apr 15;75(8):1691-702.

2. Kim JY, et al. Oncotarget. 2016 Apr 12;7(15):20395-409.

3. Benoit YD, et al. Cell Chem Biol. 2017 Jul 20;24(7):833-844.e9.

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