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Chemical Structure : CWP-232228
CAS No.: 1144044-02-9
Catalog No.: PC-61809Not For Human Use, Lab Use Only.
CWP-232228 is a highly potent small-molecule Wnt/β-catenin signaling inhibitor that targets the β-catenin/Tcf4 interaction in the nucleus.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $478 | In stock | |
| 10 mg | $758 | In stock | |
| 25 mg | Get quote | ||
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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CWP-232228 is a highly potent small-molecule Wnt/β-catenin signaling inhibitor that targets the β-catenin/Tcf4 interaction in the nucleus.
CWP-232228 preferentially inhibits the growth of breast cancer stem cells (BCSC) as well as bulk tumor cells.
CWP-232228 inhibits β-catenin-mediated transcription and attenuates IGF-I-mediated BCSC functions.
CWP-232228 reduces tumor growth in a murine xenograft model.
| M.Wt | 717.63 | |
| Formula | C33H34N7Na2O7P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Sodium 4-(((6S,9aS)-2-allyl-1-(benzylcarbamoyl)-8-((2-methyl-2H-indazol-7-yl)methyl)-4,7-dioxooctahydro-1H-pyrazino[2,1-c][1,2,4]triazin-6-yl)methyl)phenyl phosphate |
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1. Jang GB, et al. Cancer Res. 2015 Apr 15;75(8):1691-702.
2. Kim JY, et al. Oncotarget. 2016 Apr 12;7(15):20395-409.
3. Benoit YD, et al. Cell Chem Biol. 2017 Jul 20;24(7):833-844.e9.
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