CX797 | CXCR2 antagonist | Probechem Biochemicals

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Chemical Structure : CX797

CX797 (CX-797, CX 797)

Catalog No.: PC-60626Not For Human Use, Lab Use Only.

CX797 is a potent, specfic CXCR2 antagonist that inhibits IL8 down-regulation of forskolin-induced cAMP with IC50 of 7.79 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CX797 is a potent, specfic CXCR2 antagonist that inhibits IL8 down-regulation of forskolin-induced cAMP with IC50 of 7.79 uM.
CX797 inhibits IL8-mediated cAMP signaling and receptor degradation while specifically up-regulating IL8-mediated β-arrestin-2 recruitment.
CX797 also inhibits IL8-mediated cell migration.

Physicochemical Properties

M.Wt	382.5
Formula	C19H18N4OS2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-6-methyl-1-(methylthio)-4-phenyl-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one

References

1. Ha H, et al. Mol Pharm. 2014 Jul 7;11(7):2431-41.

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CX797 (CX-797, CX 797)

Biological Activity

Physicochemical Properties

References

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