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CX797

Chemical Structure : CX797

CAS No.: 1611496-70-8

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CX797 (CX-797, CX 797)

Catalog No.: PC-60626Not For Human Use, Lab Use Only.

CX797 is a potent, specfic CXCR2 antagonist that inhibits IL8 down-regulation of forskolin-induced cAMP with IC50 of 7.79 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CX797 is a potent, specfic CXCR2 antagonist that inhibits IL8 down-regulation of forskolin-induced cAMP with IC50 of 7.79 uM.
    CX797 inhibits IL8-mediated cAMP signaling and receptor degradation while specifically up-regulating IL8-mediated β-arrestin-2 recruitment.
    CX797 also inhibits IL8-mediated cell migration.

    Physicochemical Properties

    M.Wt 382.5
    Formula C19H18N4OS2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-6-methyl-1-(methylthio)-4-phenyl-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one

    References

    1. Ha H, et al. Mol Pharm. 2014 Jul 7;11(7):2431-41.

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