CXCR2-IN-1 |CAS:1873376-49-8 Probechem Biochemicals

You are here:Home-Chemical Inhibitors & Agonists-GPCR-Chemokine Receptor (CCR and CXCR)-CXCR2-IN-1

Chemical Structure : CXCR2-IN-1

CAS No.: 1873376-49-8

CXCR2-IN-1

Catalog No.: PC-42300Not For Human Use, Lab Use Only.

CXCR2-IN-1 is a potent, CNS penetrant CXCR2 antagonist with pIC50 of 9.3.

Packing	Price	Stock
5 mg	$88	In stock
25 mg	$198	In stock
50 mg	$328	In stock
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CXCR2-IN-1 is a potent, CNS penetrant CXCR2 antagonist with pIC50 of 9.3.
CXCR2-IN-1 shows neutrophil chemotaxis inhibition with pIC50 of 7.6.
CXCR2-IN-1 has developability profiles (CYP inhibition pIC<5.0, and hERG binding affinity pIC<4.0).
CXCR2-IN-1 exhibits favorable PK profile, reasonable CNS penetration, and good developability potential; orally bioavailable.

Physicochemical Properties

M.Wt	476.3492032
Formula	C19H20Cl2FN3O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥5.4 mg/mL (Need ultrasonic and warming)
Chemical Name/SMILES	Urea, N-(2-chloro-3-fluorophenyl)-N'-[4-chloro-2-hydroxy-3-[(1-methyl-4-piperidinyl)sulfonyl]phenyl]-

References

1. Xu H, et al. ACS Med Chem Lett. 2016 Feb 8;7(4):397-402.

Overnight Delivery
Fast & Safe Delivery Worldwide
Rewards Program

About Us

Our Services

Site Map

Join with Us
Product Use Citations

Pharmacological Glossary Abbreviations

Abbreviations

Quality Manual

Inquiry Form
How to Order

Terms & Conditions

Credit Card Payment

Shipping Rates & Policies

Privacy Policy
sales@probechem.com

CXCR2-IN-1

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.