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CXCR2-IN-1

Chemical Structure : CXCR2-IN-1

CAS No.: 1873376-49-8

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CXCR2-IN-1

Catalog No.: PC-42300Not For Human Use, Lab Use Only.

CXCR2-IN-1 is a potent, CNS penetrant CXCR2 antagonist with pIC50 of 9.3.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CXCR2-IN-1 is a potent, CNS penetrant CXCR2 antagonist with pIC50 of 9.3.
CXCR2-IN-1 shows neutrophil chemotaxis inhibition with pIC50 of 7.6.
CXCR2-IN-1 has developability profiles (CYP inhibition pIC<5.0, and hERG binding affinity pIC<4.0).
CXCR2-IN-1 exhibits favorable PK profile, reasonable CNS penetration, and good developability potential; orally bioavailable.

Physicochemical Properties

M.Wt 476.3492032
Formula C19H20Cl2FN3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥5.4 mg/mL (Need ultrasonic and warming)
Chemical Name/SMILES

Urea, N-(2-chloro-3-fluorophenyl)-N'-[4-chloro-2-hydroxy-3-[(1-methyl-4-piperidinyl)sulfonyl]phenyl]-

References

1. Xu H, et al. ACS Med Chem Lett. 2016 Feb 8;7(4):397-402.

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