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Chemical Structure : CYC-116
CAS No.: 693228-63-6
Catalog No.: PC-42650Not For Human Use, Lab Use Only.
CYC-116 is a potent and selective Aurora A/Aurora B inhibitor with IC50 of 8.0/9.2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | Get quote |
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CYC-116 is a potent and selective Aurora A/Aurora B inhibitor with IC50 of 8.0/9.2 nM.
CYC-116 shows >50-fold selectivity over CDK1/2/4/7/9.
CYC-116 exhibits antiproliferative activity against a broad panel of cancer cell lines with IC50<1 uM.
CYC-116 is orally bioavailable and possesses anticancer activity in mice.
| M.Wt | 368.456 | |
| Formula | C18H20N6OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Pyrimidinamine, 4-(2-amino-4-methyl-5-thiazolyl)-N-[4-(4-morpholinyl)phenyl]- |
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1. Wang S, et al. J Med Chem. 2010 Jun 10;53(11):4367-78.
2. Zhou YH, et al. Chin J Integr Med. 2015 Aug;21(8):635-9.
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