Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Cell Cycle/DNA Damage-Aurora Kinase-CYC-116
CYC-116

Chemical Structure : CYC-116

CAS No.: 693228-63-6

Add to Favorites

CYC-116 (CYC 116;CYC116)

Catalog No.: PC-42650Not For Human Use, Lab Use Only.

CYC-116 is a potent and selective Aurora A/Aurora B inhibitor with IC50 of 8.0/9.2 nM.

Packing Price Stock Quantity
10 mg $88 In stock
25 mg $138 In stock
50 mg $228 In stock
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CYC-116 is a potent and selective Aurora A/Aurora B inhibitor with IC50 of 8.0/9.2 nM.
CYC-116 shows >50-fold selectivity over CDK1/2/4/7/9.
CYC-116 exhibits antiproliferative activity against a broad panel of cancer cell lines with IC50<1 uM.
CYC-116 is orally bioavailable and possesses anticancer activity in mice.

Physicochemical Properties

M.Wt 368.456
Formula C18H20N6OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Pyrimidinamine, 4-(2-amino-4-methyl-5-thiazolyl)-N-[4-(4-morpholinyl)phenyl]-

References

1. Wang S, et al. J Med Chem. 2010 Jun 10;53(11):4367-78.

2. Zhou YH, et al. Chin J Integr Med. 2015 Aug;21(8):635-9.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: