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Chemical Structure : CYD19
CAS No.: 2415281-52-4
Catalog No.: PC-38205Not For Human Use, Lab Use Only.
Snail inhibitor CYD19 (CYD19) is a small-molecule compound that binds to the zinc finger transcription factor Snail (Kd=0.18 uM), and disrupts Snail interaction with CBP/p300.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $378 | In stock | |
| 25 mg | $588 | In stock | |
| 100 mg | Get quote |
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Snail inhibitor CYD19 (CYD19) is a small-molecule compound that binds to the zinc finger transcription factor Snail (Kd=0.18 uM), and disrupts Snail interaction with CBP/p300.
Snail inhibitor CYD19 impairs CBP/p300-mediated Snail acetylation and then promotes its degradation through the ubiquitin-proteasome pathway in aggressive cancer cells.
CYD19 restores Snail-dependent repression of wild-type p53, thus reducing tumor growth and survival in vitro and in vivo.
| M.Wt | 488.545 | |
| Formula | C24H21FN8OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(2-amino-4-fluorophenyl)-4-(((4-((5-methyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)thio)methyl)benzamide |
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1. Hong-Mei Li, et al. Sci Adv. 2020 Apr 22;6(17):eaaw8500.
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