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CYP11B1-IN-25

Chemical Structure : CYP11B1-IN-25

CAS No.: 2101952-78-5

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CYP11B1-IN-25 (CYP11B1 Inhibitor C25)

Catalog No.: PC-61692Not For Human Use, Lab Use Only.

CYP11B1-IN-25 is a selective, potent 11β-hydroxylase (CYP11B1) inhibitor with IC50 of 2 nM, displays 14-fold selectivity over CYP11B2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CYP11B1-IN-25 is a selective, potent 11β-hydroxylase (CYP11B1) inhibitor with IC50 of 2 nM, displays 14-fold selectivity over CYP11B2.
    CYP11B1-IN-25 inhibits rat CYP11B1 in V79MZ cells expressing recombinant rat CYP11B1 with IC50 of 1.8 uM.
    CYP11B1-IN-25 shows a high oral bioavailability (F = 50%) and sufficient plasma concentrations in rats, improved pharmacological profile for treatment of Cushing's disease.

    Physicochemical Properties

    M.Wt 266.3
    Formula C16H14N2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-((5-methoxypyridin-3-yl)methyl)-3-phenylisoxazole

    References

    1. Emmerich J, et al. J Med Chem. 2017 Jun 22;60(12):5086-5098.

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