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Chemical Structure : CYP11B1-IN-25
Catalog No.: PC-61692Not For Human Use, Lab Use Only.
CYP11B1-IN-25 is a selective, potent 11β-hydroxylase (CYP11B1) inhibitor with IC50 of 2 nM, displays 14-fold selectivity over CYP11B2.
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CYP11B1-IN-25 is a selective, potent 11β-hydroxylase (CYP11B1) inhibitor with IC50 of 2 nM, displays 14-fold selectivity over CYP11B2.
CYP11B1-IN-25 inhibits rat CYP11B1 in V79MZ cells expressing recombinant rat CYP11B1 with IC50 of 1.8 uM.
CYP11B1-IN-25 shows a high oral bioavailability (F = 50%) and sufficient plasma concentrations in rats, improved pharmacological profile for treatment of Cushing's disease.
| M.Wt | 266.3 | |
| Formula | C16H14N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Emmerich J, et al. J Med Chem. 2017 Jun 22;60(12):5086-5098.
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