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Chemical Structure : CYP1B1 inhibitor TMS
CAS No.: 24144-92-1
Catalog No.: PC-45614Not For Human Use, Lab Use Only.
TMS is a potent and selective inhibitor of the EROD activity of P450 1B1 (CYP1B1) with IC50 of 6 nM
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $68 | In stock | |
| 25 mg | $118 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $298 | In stock | |
| 250 mg | Get quote |
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TMS is a potent and selective inhibitor of the EROD activity of P450 1B1 (CYP1B1) with IC50 of 6 nM.
TMS exhibits 50-fold selectivity for P450 1B1 over P450 1A1 (IC50=300 nM) and 500-fold selectivity for P450 1B1 over P450 1A2 (IC50=3 uM).
TMS blocks the conversion of estradiol to 4-OH-estradiol, inhibits tubulin polymerization and microtubule formation, causes cell cycle block at the G2-M phase, and induces apoptosis.
TMS significantly attenuates hypoxic PAH and hypoxic+SU5416 PAH in vivo (3mg/kg, i.p.).
| M.Wt | 300.349 | |
| Formula | C18H20O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzene, 1-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl]-2,4-dimethoxy- |
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1. Chun YJ, et al. Cancer Res. 2001 Nov 15;61(22):8164-70.
2. Park H, et al. Cancer Res. 2007 Jun 15;67(12):5717-26.
3. White K, et al. Circulation. 2012 Aug 28;126(9):1087-98.
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