Chemical Structure : CYP4A11 and CYP4F2 inhibitor 15
CAS No.:
2280834-99-1
CYP4A11 and CYP4F2 inhibitor 15
Catalog No.: PC-23328Not For Human Use, Lab Use Only.
CYP4A11 and CYP4F2 inhibitor 15 is a potent, dual inhibitor of cytochrome P450 (CYP) 4F2 and CYP4A11 (CYP4A11/4F2) with IC50 of 120/220 nM respectively, exhibits potent suppression of 20-HETE production in both human and rat renal microsomes with IC50 of 18 nM and 37 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CYP4A11 and CYP4F2 inhibitor 15 is a potent, dual inhibitor of cytochrome P450 (CYP) 4F2 and CYP4A11 (CYP4A11/4F2) with IC50 of 120/220 nM respectively, exhibits potent suppression of 20-HETE production in both human and rat renal microsomes with IC50 of 18 nM and 37 nM.
CYP4A11/4F2 inhibitor 15 displays high selectivity over CYP4F22 (IC50=2900 nM).
CYP4A11/4F2 inhibitor 15 does not inhibit ω-hydroxylation of ULCFAs in human keratinocytes.
CYP4A11/4F2 inhibitor 15 significantly inhibited renal 20-HETE production after oral administration.
Physicochemical Properties
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M.Wt
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361.44
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Formula
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C19H27N3O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-Methyl-2-[(7-{[6-(1H-pyrazol-5-yl)pyridin-3-yl]oxy}heptyl)oxy]propanoic acid
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References
1. Madoka Kawamura, et al. Bioorg Med Chem. 2023 Oct 18:95:117505.
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