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Chemical Structure : CYP4A11 and CYP4F2 inhibitor 15
Catalog No.: PC-23328Not For Human Use, Lab Use Only.
CYP4A11 and CYP4F2 inhibitor 15 is a potent, dual inhibitor of cytochrome P450 (CYP) 4F2 and CYP4A11 (CYP4A11/4F2) with IC50 of 120/220 nM respectively, exhibits potent suppression of 20-HETE production in both human and rat renal microsomes with IC50 of 18 nM and 37 nM.
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CYP4A11 and CYP4F2 inhibitor 15 is a potent, dual inhibitor of cytochrome P450 (CYP) 4F2 and CYP4A11 (CYP4A11/4F2) with IC50 of 120/220 nM respectively, exhibits potent suppression of 20-HETE production in both human and rat renal microsomes with IC50 of 18 nM and 37 nM.
CYP4A11/4F2 inhibitor 15 displays high selectivity over CYP4F22 (IC50=2900 nM).
CYP4A11/4F2 inhibitor 15 does not inhibit ω-hydroxylation of ULCFAs in human keratinocytes.
CYP4A11/4F2 inhibitor 15 significantly inhibited renal 20-HETE production after oral administration.
| M.Wt | 361.44 | |
| Formula | C19H27N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Madoka Kawamura, et al. Bioorg Med Chem. 2023 Oct 18:95:117505.
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