Chemical Structure : CYT387 mesylate
CAS No.:
1056636-07-7
CYT387 mesylate
(CYT 387 mesylate;CYT-387 mesylate;Momelotinib mesylate)
Catalog No. : PC-42753Not For Human Use, Lab Use Only.
A potent and selective JAK1/JAK2 inhibitor with IC50 of 11/18 nM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4275301
Biological Activity
A potent and selective JAK1/JAK2 inhibitor with IC50 of 11/18 nM; shows significantly less activity against other kinases, including JAK3 (IC50=155 nM); inhibits JAK2V617F (JH1-JH2) withIC50 of 11 nM; inhibits growth of Ba/F3-JAK2V617F and HEL cells (IC50=1500 nM) or Ba/F3-MPLW515L cells (IC50=200 nM).
Bone Cancer
Phase 3 Clinical
Physicochemical Properties
M.Wt
510.5654
Formula
C24H26N6O5S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Benzamide, N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-, methanesulfonate (1:x)
References
1. Pardanani A, et al. Leukemia. 2009 Aug;23(8):1441-5.
2. Burns CJ, et al. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5887-92.
3. Tyner JW, et al. Blood. 2010 Jun 24;115(25):5232-40.
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