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CYT387 sulfate

Chemical Structure : CYT387 sulfate

CAS No.: 1056636-06-6

CYT387 sulfate (CYT-387 sulfate, Momelotinib sulfate)

Catalog No.: PC-42752Not For Human Use, Lab Use Only.

Momelotinib (CYT387) sulfate is a potent and selective JAK1/JAK2 inhibitor with IC50 of 11/18 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Momelotinib (CYT387) sulfate is a potent and selective JAK1/JAK2 inhibitor with IC50 of 11/18 nM.
Momelotinib shows significantly less activity against other kinases, including JAK3 (IC50=155 nM).
Momelotinib inhibits JAK2V617F (JH1-JH2) withIC50 of 11 nM.
Momelotinib inhibits growth of Ba/F3-JAK2V617F and HEL cells (IC50=1500 nM) or Ba/F3-MPLW515L cells (IC50=200 nM).

Physicochemical Properties

M.Wt 610.6168
Formula C23H26N6O10S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥ 6.1 mg/mL

Chemical Name/SMILES

Benzamide, N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-, sulfate (1:2)

References

1. Pardanani A, et al. Leukemia. 2009 Aug;23(8):1441-5.

2. Burns CJ, et al. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5887-92.

3. Tyner JW, et al. Blood. 2010 Jun 24;115(25):5232-40.

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