Chemical Structure : CZ-48
CAS No.:
1374663-29-2
CZ-48
(Sulfo-ara-F-NMN)
Catalog No.: PC-26389Not For Human Use, Lab Use Only.
CZ-48 (Sulfo-ara-F-NMN) is a mimetic of nicotinamide mononucleotide (NMN) and selective cell-permeant activator of SARM1, activate SARM1 to produce cADPR from NAD, does not inhibit CD38.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CZ-48 (Sulfo-ara-F-NMN) is a mimetic of nicotinamide mononucleotide (NMN) and selective cell-permeant activator of SARM1, activate SARM1 to produce cADPR from NAD, does not inhibit CD38.
CZ-48 induced increase in the cADPR levels in SARM1-expressing cells.
CZ-48 activates SARM1 via a conformational change of the auto-inhibitory domain and dimerization of its catalytic domain.
CZ-48 mimics cellular NMN in activating SARM1 enzymatically.
CZ-48 elevates cADPR, depletes NAD and ATP, and induces non-apoptotic death in SARM1-overexpressing cells.
Physicochemical Properties
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M.Wt
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352.27
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Formula
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C11H14FN2O6PS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O-(((2R,3R,4S,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl)methyl) S-hydrogen phosphorothioate
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References
1. Zhao ZY, et al. iScience. 2019 May 31;15:452-466.
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