CZL80 | Caspase-1 inhibitor | Probechem Biochemicals

Chemical Structure : CZL80

CZL80 (Caspase-1 inhibitor CZL80)

Catalog No.: PC-22034Not For Human Use, Lab Use Only.

Caspase-1 inhibitor CZL80 is a potent, selective, brain‐penetrable Caspase-1 inhibitor with IC50 of 0.01 uM.

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Biological Activity

Caspase-1 inhibitor CZL80 is a potent, selective, brain‐penetrable Caspase-1 inhibitor with IC50 of 0.01 uM.
CZL80 markedly reduced neuronal excitability and incidence of febrile seizures (FS) generation in neonatal mice.
CZL80 relieves later enhanced epileptogenic susceptibility in adult mice.
CZL80 is devoid of acute diazepam‐like respiratory depression and chronic liver toxicity.
CZL80 promotes the neurological recovery in PIS by inhibiting Caspase-1 within a long therapeutic time-window in mice with progressive ischemic stroke (PIS).

Physicochemical Properties

M.Wt	366.39
Formula	C19H14N2O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-(thiophene-2-carboxamido)benzamido)benzoic acid

References

1. Tang Y, et al. Br J Pharmacol. 2020 Aug;177(15):3519-3534.

2. Pan L, et al. Acta Pharmacol Sin. 2022 Nov;43(11):2817-2827.

CZL80 (Caspase-1 inhibitor CZL80)

Biological Activity

Physicochemical Properties

References

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