Caf1 inhibitor 8j

Chemical Structure : Caf1 inhibitor 8j

Catalog No.: PC-20454Not For Human Use, Lab Use Only.

Caf1 inhibitor 8j is a potent, selective inhibitor of human poly(A)-selective ribonuclease Caf1 with IC50 of 0.59 uM, 40-fold selectivity over the related deadenylase PARN.

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Biological Activity

Caf1 inhibitor 8j is a potent, selective inhibitor of human poly(A)-selective ribonuclease Caf1 with IC50 of 0.59 uM, 40-fold selectivity over the related deadenylase PARN.

Physicochemical Properties

M.Wt	357.41
Formula	C18H23N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-(dimethylamino)propyl)-1-hydroxy-7-phenethyl-3,7-dihydro-1H-purine-2,6-dione

References

1. Gopal P Jadhav, et al. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4219-24.

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