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Caffeic acid phenethyl ester

Chemical Structure : Caffeic acid phenethyl ester

CAS No.: 115610-29-2

Caffeic acid phenethyl ester (CAPE)

Catalog No.: PC-27821Not For Human Use, Lab Use Only.

Caffeic acid phenethyl ester (CAPE) is an active component of propolis and has an antiproliferative property in cancer cell lines via inhibition of NF-κB signaling, downregulation of inhibitor of apoptosis (IAP) family proteins, and modulation of the balance of Bcl-2 family members, inhibits human Glyoxalase I (hGLO I) with IC50 of 7.9 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Caffeic acid phenethyl ester (CAPE) is an active component of propolis and has an antiproliferative property in cancer cell lines via inhibition of NF-κB signaling, downregulation of inhibitor of apoptosis (IAP) family proteins, and modulation of the balance of Bcl-2 family members, inhibits human Glyoxalase I (hGLO I) with IC50 of 7.9 uM.

Physicochemical Properties

M.Wt 284.31
Formula C17H16O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

phenethyl (E)-3-(3,4-dihydroxyphenyl)acrylate

References

1. Ishizaki S, et al. Bioorg Med Chem Lett. 2026 Aug 21:130762.

2. P. Pandey, et al. Chem Biol Drug Des, 102 (2023), pp. 201-216,

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