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Caficrestat

Chemical Structure : Caficrestat

CAS No.: 1355612-71-3

Caficrestat (AT-001, Aldose reductase-IN-1)

Catalog No.: PC-45580Not For Human Use, Lab Use Only.

AT-001 (Caficrestat) is a highly potent, selective inhibitor of aldose reductase enzymatic activity with IC50 of 28.9 pM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AT-001 (Caficrestat) is a highly potent, selective inhibitor of aldose reductase enzymatic activity with IC50 of 28.9 pM.
AT-001 (Caficrestat) decreases biomarkers of myocardial stress and is currently being studied in a Phase 3 global registrational study in patients with diabetic cardiomyopathy (ARISE-HF).
AT-001 (Caficrestat) reduces viral inflammation and risk of adverse outcomes in diabetic patients with COVID-19.

Physicochemical Properties

M.Wt 421.3532
Formula C17H10F3N5O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 28 mg/mL

Chemical Name/SMILES

Pyrazino[2,3-d]pyridazine-5-acetic acid, 7,8-dihydro-8-oxo-7-[[5-(trifluoromethyl)-2-benzothiazolyl]methyl]-

References

1. Juan Gaztanaga, et al. Diabetes Metab Syndr. Nov-Dec 2021;15(6):102328.

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