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Chemical Structure : Calhex-231
CAS No.: 652973-93-8
Catalog No.: PC-62905Not For Human Use, Lab Use Only.
Calhex-231 is a potent negative allosteric modulator of CaSR that blocks calcium-mediated activation with IC50 of 0.39 uM.
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|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Calhex-231 is a potent negative allosteric modulator of CaSR that blocks calcium-mediated activation with IC50 of 0.39 uM.
Calhex-231 inhibits myocyte hyperpolarization to the CaSR activator calindol and R-568.
| M.Wt | 406.954 | |
| Formula | C25H27ClN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide |
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1. Petrel C, et al. J Biol Chem. 2003 Dec 5;278(49):49487-94.
2. Weston AH, et al. Circ Res. 2005 Aug 19;97(4):391-8.
3. Kessler A, et al. J Med Chem. 2006 Aug 24;49(17):5119-28.
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