Chemical Structure : Calindol hydrochloride
CAS No.:
729610-18-8
Calindol hydrochloride
Catalog No.: PC-62910Not For Human Use, Lab Use Only.
Calindol hydrochloride is a calcimimetic acting agent and positive allosteric modulator (agonist) of CaSR with EC50 of 0.31 uM (stimulated 3H IP accumulation in CHO cells at 2 mM Ca2+).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Calindol hydrochloride is a calcimimetic acting agent and positive allosteric modulator (agonist) of CaSR with EC50 of 0.31 uM (stimulated 3H IP accumulation in CHO cells at 2 mM Ca2+); activates an extracellular ligand-binding domain-deleted rhodopsin-like seven-transmembrane structure in the absence of Ca(2+); produces concentration-dependent hyperpolarizations of vascular myocytes from rat isolated mesenteric and porcine coronary arteries.
Physicochemical Properties
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M.Wt
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336.863
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Formula
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C21H21ClN2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-[(1R)-1-(1-naphthalenyl)ethyl]-1H-indole-2-methanamine, monohydrochloride
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References
1. Kessler A, et al. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3345-9.
2. Weston AH, et al. Circ Res. 2005 Aug 19;97(4):391-8.
3. Ray K, et al. J Biol Chem. 2005 Nov 4;280(44):37013-20.
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