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Calyculin A

Chemical Structure : Calyculin A

CAS No.: 101932-71-2

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Calyculin A ((-)-Calyculin A)

Catalog No.: PC-45587Not For Human Use, Lab Use Only.

Calyculin A is a more potent phosphatase inhibitor than Okadaic acid, inhibits catalytic subunit of type-2A phosphatase (IC50 =0.5-1 nM), calyculin A is more effective for protein phosphatase type-1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Calyculin A is a more potent phosphatase inhibitor than Okadaic acid, inhibits catalytic subunit of type-2A phosphatase (IC50 =0.5-1 nM), calyculin A is more effective for protein phosphatase type-1.

Physicochemical Properties

M.Wt 1009.17
Formula C50H81N4O15P
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

L-Ribonamide, N-[(3S)-3-[4-[(1E)-3-[(2R,3R,5R,7S,8S,9R)-2-[(1S,3S,4S,5R,6R,7E,9E,11E,13Z)-14-cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraen-1-yl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-pr

References

1. Ishihara H, et al. Biochem Biophys Res Commun. 1989 Mar 31;159(3):871-7.

2. Resjö S, et al. Biochem J. 1999 Aug 1;341 ( Pt 3):839-45.

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