Cangrelor (AR-C69931MX) is a potent, selective P2T/P2Y12 receptor antagonist with IC50 of 0.4 nM against ADP-induced aggregation of human platelets.
Cangrelor (AR-C69931MX) displays >1,000-fold selectivity over other P2 receptor family.
Cangrelor (AR-C69931MX) antagonizes the ex vivo and in vivo aggregatory actions of ADP, and displays a rapid onset and offset of action with the ability to prevent occlusive arterial thrombus formation.
Physicochemical Properties
M.Wt
776.36
Formula
C17H25Cl2F3N5O12P3S2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
5'-Adenylic acid, N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-, monoanhydride with (dichloromethylene)bis[phosphonic acid] (9CI)
References
1. Ingall AH, et al. J Med Chem. 1999 Jan 28;42(2):213-20.
