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Chemical Structure : Cantrixil
Catalog No.: PC-20927Not For Human Use, Lab Use Only.
Cantrixil (TRX-E-002-1) is a potent inducer of CD44+/MyD88+ ovarian cancer stem cell (OCSC) death with IC50 of 47 nM.
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Cantrixil (TRX-E-002-1) is a potent inducer of CD44+/MyD88+ ovarian cancer stem cell (OCSC) death with IC50 of 47 nM.
Cantrixil (TRX-E-002-1) induces cell death by the activation and enhanced expression of c-Jun, leading to the induction of caspases.
Cantrixil (TRX-E-002-1) is effective against both clones and was able to decrease the percentage of viable cells with IC50 of 68 nmol/L and 27 nmol/L for chemosensitive ovarian cancer cells (OCC1 and OCC2) respectively.
TRX-E-002-1 is effective in inducing death in 3D ovarian cancer spheroids, prevents OCSC recurrence in vitro.
TRX-E-002-1-induced cell death is associated with phosphorylation and increased expression levels of c-Jun, activates the caspase cascade and requires c-Jun activation.
TRX-E-002-1 (100 mg/kg daily, i.p.) demonstrates significant antitumor activity against both primary and recurrent disease in a mouse xenograft model of ovarian cancer.
The combination of TRX-E-002-1 and cisplatin is able to decrease tumor kinetics better than monotherapy.
| M.Wt | 408.45 | |
| Formula | C24H24O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Alvero AB, et al. Mol Cancer Ther. 2016 Jun;15(6):1279-90.
2. Saif MW, et al. Cancer Chemother Pharmacol. 2017 Feb;79(2):303-314.
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