Chemical Structure : Capsazepine
CAS No.: 138977-28-3
Catalog No.: PC-22981Not For Human Use, Lab Use Only.
Capsazepine is a selective antagonist of vanilloid receptor TRPV1 with IC50 of 562 nM.
Packing | Price | Stock | Quantity |
---|---|---|---|
10 mg | $78 | In stock | |
25 mg | $128 | In stock | |
50 mg | $218 | In stock | |
100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Capsazepine is a selective antagonist of vanilloid receptor TRPV1 with IC50 of 562 nM.
Capsazepine inhibited [(3)H]RTX binding to HEK293/VR1 cells with a K(i) value of 6.2 microM and binding to DRG membranes with a K(i) value of 8.6 microM.
Capsazepine induces ROS generation and ROS mediate Capsazepine-induced DR5 upregulation in HCT116 cells.
M.Wt | 376.90 | |
Formula | C19H21ClN2O2S | |
Appearance | Solid | |
Storage |
|
|
Solubility |
10 mM in DMSO |
|
Chemical Name/SMILES |
N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide |
1. Szallasi A, et al. Mol Pharmacol. 1999 Sep;56(3):581-7.
2. Smart D, et al. Br J Pharmacol. 2000 Jan;129(2):227-30.
3. Trevisani M, et al. Nat Neurosci. 2002 Jun;5(6):546-51.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright