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Capsazepine

Chemical Structure : Capsazepine

CAS No.: 138977-28-3

Capsazepine

Catalog No.: PC-22981Not For Human Use, Lab Use Only.

Capsazepine is a selective antagonist of vanilloid receptor TRPV1 with IC50 of 562 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Capsazepine is a selective antagonist of vanilloid receptor TRPV1 with IC50 of 562 nM.
Capsazepine inhibited [(3)H]RTX binding to HEK293/VR1 cells with a K(i) value of 6.2 microM and binding to DRG membranes with a K(i) value of 8.6 microM.
Capsazepine induces ROS generation and ROS mediate Capsazepine-induced DR5 upregulation in HCT116 cells.

Physicochemical Properties

M.Wt 376.90
Formula C19H21ClN2O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide

References

1. Szallasi A, et al. Mol Pharmacol. 1999 Sep;56(3):581-7.

2. Smart D, et al. Br J Pharmacol. 2000 Jan;129(2):227-30.

3. Trevisani M, et al. Nat Neurosci. 2002 Jun;5(6):546-51.

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