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Chemical Structure : Capzimin
CAS No.: 2084867-65-0
Catalog No.: PC-60898Not For Human Use, Lab Use Only.
Capzimin (Rpn11 inhibitor 3027) is a derivative of 8TQ, and potent and specific inhibitor of proteasome isopeptidase Rpn11 (PSMD14) with IC50 of 0.34 uM, >7-fold improved potency over 8TQ (quinoline-8-thiol).
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|---|---|---|---|
| 5 mg | $488 | In stock | |
| 10 mg | $728 | In stock | |
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| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Capzimin (Rpn11 inhibitor 3027) is a derivative of 8TQ, and potent and specific inhibitor of proteasome isopeptidase Rpn11 (PSMD14) with IC50 of 0.34 uM, >7-fold improved potency over 8TQ (quinoline-8-thiol).
Capzimin shows >5-fold selectivity for Rpn11 over the related JAMM proteases and >2 logs less activity towards metalloenzymes (HDAC6, MMP2, MMP12, and carbonic anhydrase II).
Capzimin stabilizes proteasome substrates, induced an unfolded protein response, and blocks proliferation of cancer cells (HCT116 GI50=2.0 uM), including bortezomib-resistant retinal pigment epithelial cells.
| M.Wt | 315.409 | |
| Formula | C15H13N3OS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
8-Mercapto-N-(2-(thiazol-2-yl)ethyl)quinoline-3-carboxamide |
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1. Li J, et al. Nat Chem Biol. 2017 May;13(5):486-493.
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