Capzimin | Rpn11 inhibitor | Probechem Biochemicals

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Chemical Structure : Capzimin

CAS No.: 2084868-04-0

Capzimin (Rpn11 inhibitor 35)

Catalog No.: PC-61132Not For Human Use, Lab Use Only.

Capzimin is a potent, small molecule inhibitor of the proteasome subunit Rpn11 with IC50 of 400 nM,100-fold selectivity over Csn5 and 10-fold selectivity over AMSH.

Packing	Price	Stock
5 mg	$98	In stock
10 mg	$148	In stock
25 mg	$258	In stock
50 mg	$428	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Capzimin is a potent, small molecule inhibitor of the proteasome subunit Rpn11 with IC50 of 400 nM,100-fold selectivity over Csn5 and 10-fold selectivity over AMSH.
Capzimin inhibits 293T and A549 cells proliferation with IC50 of 2.1 and 3.8 uM, respectively.

Physicochemical Properties

M.Wt	628.802
Formula	C30H24N6O2S4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8,8'-disulfanediylbis(N-(2-(thiazol-2-yl)ethyl)quinoline-3-carboxamide)

References

1. Perez C, et al. J Med Chem. 2017 Feb 23;60(4):1343-1361.

2. Li J, et al. Nat Chem Biol. 2017 May;13(5):486-493.

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Capzimin (Rpn11 inhibitor 35)

Biological Activity

Physicochemical Properties

References

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