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Carubicin

Chemical Structure : Carubicin

CAS No.: 39472-31-6

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Carubicin (Carminomycin;Carminomycin I;Carminomicin I)

Catalog No.: PC-62441Not For Human Use, Lab Use Only.

Carubicin (Carminomycin) is an apoptosis inducer that targets the Golgi complex, induces apoptosis in CCRCC cells by a mechanism independent of p53 or HIF2, and induces cleavage of the Golgi protein p115 and the translocation of its C-terminal fragment to the nucleus..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Carubicin (Carminomycin) is an apoptosis inducer that targets the Golgi complex, induces apoptosis in CCRCC cells by a mechanism independent of p53 or HIF2, and induces cleavage of the Golgi protein p115 and the translocation of its C-terminal fragment to the nucleus.

Physicochemical Properties

M.Wt 513.499
Formula C26H27NO10
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-4,6,9,11-tetrahydroxy-8,10-dihydro-7H-tetracene-5,12-dione

References

1. Woldemichael GM, et al. Cancer Res. 2011 Jan 1;71(1):134-42.

2. Tevyashova AN, et al. J Antibiot (Tokyo). 2004 Feb;57(2):143-50.

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