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Chemical Structure : Cbl-b inhibitor 25
Catalog No.: PC-21631Not For Human Use, Lab Use Only.
Cbl-b inhibitor 25 is a potent, selective inhibitor of RING finger E3 ligase Cbl-b with IC50 of 15 nM in TR-FRET assays.
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Cbl-b inhibitor 25 is a potent, selective inhibitor of RING finger E3 ligase Cbl-b with IC50 of 15 nM in TR-FRET assays.
Cbl-b inhibitor 25 induces IL-2 production with EC50 of 0.41 uM in a T-cell IL-2 secretion assay.
Cbl-b inhibitor 25 binds to the TKB/RING domain of Cbl-b.
Cbl-b inhibitor 25 increases hosphorylated-PLCγ (pPLCγ) and inhibits Cbl-b ubiquitination of ZAP70, arrests E3 ligase function on downstream TCR signaling proteins as well as its own autoubiquitination.
| M.Wt | 469.55 | |
| Formula | C27H27N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jeffrey A Boerth, et al. ACS Med Chem Lett. 2023 Nov 17;14(12):1848-1856.
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