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Chemical Structure : Cdk5 inhibitor 25-106
Catalog No.: PC-47009Not For Human Use, Lab Use Only.
Cdk5 inhibitor 25-106 is a potent, brain-penetrant inhibitor of Cdk5/p35 activity with IC50 of 178 nM.
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Cdk5 inhibitor 25-106 is a potent, brain-penetrant inhibitor of Cdk5/p35 activity with IC50 of 178 nM.
Cdk5 inhibitor 25-106 demonstrated similar inhibition against highly homologous Cdk2/Cyclin E (IC50=149 nM), and weak inhibition against CDK9/Cyclin T1 (IC50=5710 nM) in in vitro selectivity assays.
25-106 significantly reduced phospho-Ser549 synapsin I levels in the striatum 2 h after I.V. injection.
25-106 inhibits Cdk5 activity in vivo and displays high potency for inhibition in vitro.
25-106 (50 mg/kg) displayed an increased latency to suspend immobility and displayed a reduction in total immobility time as compared to vehicle-injected mice, modulated behavioral phenotypes linked to Cdk5 through previous characterizations of conditional knockout mice.
| M.Wt | 345.399 | |
| Formula | C18H23N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Umfress A, et al. Front Pharmacol. 2022 May 12;13:863762.
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