Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Cediranib maleate
CAS No.: 857036-77-2
Catalog No.: PC-43353Not For Human Use, Lab Use Only.
A highly potent, orally bioavailable, pan-VEGFR inibitor with IC50 of 1, 5, 3 nM for VEGFR1, 2, 3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $72 | In stock | |
| 50 mg | $264 | In stock | |
| 100 mg | $368 | In stock |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
A highly potent, orally bioavailable, pan-VEGFR inibitor with IC50 of 1, 5, 3 nM for VEGFR1, 2, 3, respectively; also inhibits c-Kit and PDGFRβ with IC50 of 2 and 5 nM, >36-fold selectivity over PDGFR-α, >1000-fold over Flt-3 and EGFR; inhibits VEGF-stimulated proliferation and KDR phosphorylation with IC50 of 0.4 and 0.5 nM in human umbilical vein endothelial cells; inhibits angiogenesis, neovascular survival and tumor growth in vivo.
Ovarian Cancer
Phase 3 Clinical
| M.Wt | 566.5775 | |
| Formula | C29H31FN4O7 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO: ≥ 45 mg/mL |
|
| Chemical Name/SMILES |
Quinazoline, 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]-, (2Z)-2-butenedioate (1:1) |
|
1. Wedge SR, et al. Cancer Res. 2005 May 15;65(10):4389-400.
2. Denduluri N, et al. Clin Breast Cancer. 2005 Dec;6(5):460-3.
3. Batchelor TT, et al. Cancer Cell. 2007 Jan;11(1):83-95.
4. Cao C, et al. Cancer Res. 2006 Dec 1;66(23):11409-15.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
