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Chemical Structure : Celastrol
CAS No.: 34157-83-0
Catalog No.: PC-43371Not For Human Use, Lab Use Only.
Celastrol (Tripterin) is an active compound extracted from Chinese medicine Thunder of God Vine, is a potent proteasome inhibitor, preferentially inhibits the chymotrypsin-like activity of 20S proteasome with IC50 of 2.5 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $18 | In stock | |
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
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Celastrol (Tripterin) is an active compound extracted from Chinese medicine Thunder of God Vine, is a potent proteasome inhibitor, preferentially inhibits the chymotrypsin-like activity of 20S proteasome with IC50 of 2.5 uM.
Celastrol also inhibits 26S proteasome in intact androgen-independent PC-3 and androgen-dependent LNCaP prostate cancer cells at 1-5 uM, induces apoptotic cell death, and accumulates ubiquitinated proteins and natural proteasome substrates, IκB-α, Bax, and p27, and/or suppression of AR protein expression.
Celastrol promotes significant tumor growth inhibition and massive apoptosis induction in vivo.
Celastrol also is a nonselective peroxiredoxin 1 (PRDX1) inhibitor covalently linked to the Cys-173 residue of PRDX1 via a Michael-like addition reaction.
| M.Wt | 450.6096 | |
| Formula | C29H38O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-9,13-dimethyl-2-oxo-, (9.beta.,13.alpha.,14.beta.,20.alpha.)- |
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1. Yang H, et al. Cancer Res. 2006 May 1;66(9):4758-65.
2. Yadav VR, et al. J Mol Med (Berl). 2010 Dec;88(12):1243-53.
3. Chen M, et al. Mol Cancer Res. 2009 Dec;7(12):1946-53.
4. Ge P, et al. Neurol Res. 2010 Feb;32(1):94-100.
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