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Cenisertib

Chemical Structure : Cenisertib

CAS No.: 871357-89-0

Cenisertib (R763, AS-703569, AS703569)

Catalog No.: PC-62560Not For Human Use, Lab Use Only.

Cenisertib (AS-703569, R763) is a novel potent, orally available inhibitor of Aurora kinases, exhibits signifficant anti-proliferative activity against a wide range of tumor cells both in vitro and in vivo (A549 EC50=9 nM).

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Biological Activity

Cenisertib (AS-703569, R763) is a novel potent, orally available inhibitor of Aurora kinases, exhibits signifficant anti-proliferative activity against a wide range of tumor cells both in vitro and in vivo (A549 EC50=9 nM).
Cenisertib (AS 703569, R763) demonstrates marked inhibition of tumor growth in xenograft models of pancreatic, breast, colon, ovarian, and lung tumors and leukemia.

Physicochemical Properties

M.Wt 451.54
Formula C24H30FN7O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1S,2S,3R,4R)-3-((5-fluoro-2-((3-methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)bicyclo[2.2.1]hept-5-ene-2-carboxamide

References

1. McLaughlin J, et al. J Cancer Res Clin Oncol. 2010 Jan;136(1):99-113.

2. Illert AL, et al. PLoS One. 2014 Nov 26;9(11):e112318.

3. Peter B, et al. Leukemia. 2017 Nov 29. doi: 10.1038/leu.2017.338.

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