Chemical Structure : Cenisertib
CAS No.: 871357-89-0
Catalog No.: PC-62560Not For Human Use, Lab Use Only.
Cenisertib (AS-703569, R763) is a novel potent, orally available inhibitor of Aurora kinases, exhibits signifficant anti-proliferative activity against a wide range of tumor cells both in vitro and in vivo (A549 EC50=9 nM).
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Cenisertib (AS-703569, R763) is a novel potent, orally available inhibitor of Aurora kinases, exhibits signifficant anti-proliferative activity against a wide range of tumor cells both in vitro and in vivo (A549 EC50=9 nM).
Cenisertib (AS 703569, R763) demonstrates marked inhibition of tumor growth in xenograft models of pancreatic, breast, colon, ovarian, and lung tumors and leukemia.
M.Wt | 451.54 | |
Formula | C24H30FN7O | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
(1S,2S,3R,4R)-3-((5-fluoro-2-((3-methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)bicyclo[2.2.1]hept-5-ene-2-carboxamide |
1. McLaughlin J, et al. J Cancer Res Clin Oncol. 2010 Jan;136(1):99-113.
2. Illert AL, et al. PLoS One. 2014 Nov 26;9(11):e112318.
3. Peter B, et al. Leukemia. 2017 Nov 29. doi: 10.1038/leu.2017.338.
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