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Ceranib-2

Chemical Structure : Ceranib-2

CAS No.: 1402830-75-4

Ceranib-2 (Ceranib 2)

Catalog No.: PC-25386Not For Human Use, Lab Use Only.

Ceranib-2 (Ceranib 2) is a small molecule ceramidase inhibitor with IC50 of 28 uM in cell-based assays, exhibits antiproliferative effect in SKOV3 cells with IC50 of 0.71 uM, induces the accumulation of multiple ceramide species, decreases levels of sphingosine and S1P.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Ceranib-2 (Ceranib 2) is a small molecule ceramidase inhibitor with IC50 of 28 uM in cell-based assays, exhibits antiproliferative effect in SKOV3 cells with IC50 of 0.71 uM, induces the accumulation of multiple ceramide species, decreases levels of sphingosine and S1P.

Physicochemical Properties

M.Wt 381.43
Formula C25H19NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-[3-(4-methoxyphenyl)acryloyl]-4-phenyl-1H-quinolin-2-one

References

1. Draper JM, et al. Mol Cancer Ther. 2011 Nov;10(11):2052-61.

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