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Chemical Structure : Ch-319
Catalog No.: PC-35326Not For Human Use, Lab Use Only.
Ch-319 (Ch319) is a triphenyltin (IV) carboxylate derivative that modulates AKT/FOXO3a signaling and inhibits progression of prostate cancer.
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Ch-319 (Ch319) is a triphenyltin (IV) carboxylate derivative that modulates AKT/FOXO3a signaling and inhibits progression of prostate cancer.
Ch-319 reduces viability and induces cell cycle arrest associated with downregulation of PI3K and dephosphorylation of AKT and PRAS40 in PTEN-null PC3M and DU145 PCa cells at 250-500 nM.
Ch-319 decreases tumor weights, reduces expression of androgen receptor, decreases phosphorylation of AKT and PRAS40 and increases FOXO3a in mice.
| M.Wt | 604.293 | |
| Formula | C33H27NO3Sn | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Durdana Waseem, et al. Abstract 688: Triphenylstannyl 2-(benzylcarbamoyl)benzoate (Ch-319) modulates AKT/FOXO3a signaling and inhibits progression of prostate cancer. AACR.2018.
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