Chiglitazar | PPARα/γ agonist | Probechem Biochemicals

Chemical Structure : Chiglitazar

Chiglitazar (Carfloglitazar;CS-038;CS038)

Catalog No.: PC-35795Not For Human Use, Lab Use Only.

Chiglitazar (Carfloglitazar, CS-038, CS038) is a potent, dual PPARα/γ dual agonist with EC50 of 1.2, 0.08, 1.7 uM for PPARα, PPARγ and PPARδ, respectively.

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Biological Activity

Chiglitazar (Carfloglitazar, CS-038, CS038) is a potent, dual PPARα/γ dual agonist with EC50 of 1.2, 0.08, 1.7 uM for PPARα, PPARγ and PPARδ, respectively.
Chiglitazar (Carfloglitazar, CS-038) inhibited alanine gluconeogenesis, lowered the hepatic glycogen level in MSG obese rats.
Like rosiglitazone, chiglitazar promoted the differentiation of adipocytes and decreased the maximal diameter of adipocytes.
Chiglitazar reduced plasma triglyceride, total cholesterol (TCHO), nonesterified fatty acids (NEFA) and low density lipoprotein-cholesterol levels.
Chiglitazar (Carfloglitazar, CS-038 lowered hepatic triglyceride and TCHO contents, decreased muscular NEFA level.
Unlike rosiglitazone, chiglitazar showed significant increase of mRNA expression of PPARα, CPT1, BIFEZ, ACO and CYP4A10 in the liver of MSG obese rats.

Physicochemical Properties

M.Wt	594.618
Formula	C36H28FN2NaO4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-(2-(9H-carbazol-9-yl)ethoxy)phenyl)-2-((2-(4-fluorobenzoyl)phenyl)amino)propanoic acid sodium salt

References

1. Li PP, et al. Br J Pharmacol. 2006 Jul;148(5):610-8.

2. He BK, et al. PPAR Res. 2012;2012:546548.

3. Pan DS, et al. PPAR Res. 2017;2017:4313561.

Chiglitazar (Carfloglitazar;CS-038;CS038)

Biological Activity

Physicochemical Properties

References

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