ChoKα inhibitor CK37 is a potent, specific, competitive inhibitor of choline kinase-α (Chok-α) by targeting the choline binding site.
ChoKα inhibitor CK37 significantly increases LC3II expression in MCF-7 and MCF-7/TAM cells, increases the size and number of autophagosome, causes MCF-7 and MCF-7/TAM cells to a slight increase in p62.
ChoKα inhibitor CK37 suppresses MAPK and PI3K/AKT signaling, disrupts actin cytoskeletal organization, and reduces plasma membrane ruffling.
ChoKα inhibitor CK37 significantly decreases tumor growth in a lung tumor xenograft mouse model, suppresses tumor phosphocholine, and diminishes activating phosphorylations of ERK and AKT in vivo.
