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Chemical Structure : Ciforadenant
CAS No.: 1202402-40-1
Catalog No.: PC-61367Not For Human Use, Lab Use Only.
Ciforadenant (CPI-444, V 81444) is a potent, orally active, adenosine A2A receptor antagonist that is being investigated in solid tumors as a single agent and in combination with the anti-PD-L1 antibody atezolizumab.
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|---|---|---|---|
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| 10 mg | $148 | In stock | |
| 25 mg | $268 | In stock | |
| 50 mg | $458 | In stock | |
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Ciforadenant (CPI-444, V 81444) is a potent, orally active, adenosine A2A receptor antagonist that is being investigated in solid tumors as a single agent and in combination with the anti-PD-L1 antibody atezolizumab.
Ciforadenant dose-dependent inhibits tumor growth in mouse model MC38.
Ciforadenant induces anti-tumor immunity in mouse tumor models and inhibits adenosine signaling in lymphocytes of treated humans.
| M.Wt | 407.434 | |
| Formula | C20H21N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7-(5-Methyl-2-furanyl)-3-[[6-[[[(3S)-tetrahydro-3-furanyl]oxy]methyl]-2-pyridinyl]methyl]-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine |
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1. Stephen Willingham, et al. Abstract PR04: CPI-444: DOI: 10.1158/2326-6066.IMM2016-PR04 Published November 2016
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