Cinacalcet (AMG073) | CaSR agonist | Probechem Biochemicals

Chemical Structure : Cinacalcet

CAS No.: 226256-56-0

Cinacalcet (AMG073, AMG-073)

Catalog No.: PC-45941Not For Human Use, Lab Use Only.

Cinacalcet (AMG073) is a calcimimetic agent that acts as an allosteric activator of CaSR with EC50 of 51 nM.

Packing	Price	Stock
50 mg	$88	In stock
100 mg	$128	In stock
250 mg	$198	In stock
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Biological Activity

Cinacalcet (AMG073) is a calcimimetic agent that acts as an allosteric activator of CaSR with EC50 of 51 nM.
Cinacalcet (AMG073) increases the concentration of cytoplasmic Ca(2+) in human embryonic kidney 293 cells expressing the human parathyroid CaR with EC50 of 51 nM.
Cinacalcet (AMG073) decreases PTH secretion from cultured bovine parathyroid cells with IC50 of 28 nM.
Cinacalcet (AMG073) is used for the treatment of tertiary hyperparathyroidism.

Physicochemical Properties

M.Wt	357.412
Formula	C22H22F3N
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Naphthalenemethanamine, .alpha.-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-, (.alpha.R)-

References

1. Nemeth EF, et al. J Pharmacol Exp Ther. 2004 Feb;308(2):627-35.

2. Lindberg JS, et al. Kidney Int. 2003 Jan;63(1):248-54.

3. Quarles LD, et al. J Am Soc Nephrol. 2003 Mar;14(3):575-83.

Cinacalcet (AMG073, AMG-073)

Biological Activity

Physicochemical Properties

References

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