Cinacalcet hydrochloride |CAS:364782-34-3 Probechem Biochemicals

Chemical Structure : Cinacalcet hydrochloride

CAS No.: 364782-34-3

Cinacalcet hydrochloride (AMG 073 hydrochloride;AMG073 hydrochloride;AMG-073 hydrochloride;Cinacalcet)

Catalog No.: PC-45942Not For Human Use, Lab Use Only.

Cinacalcet (AMG 073) hydrochloride is a calcimimetic agent that acts as an allosteric activator of CaSR.

Packing	Price	Stock
50 mg	$128	In stock
100 mg	$198	In stock
200 mg	$298	In stock
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Biological Activity

Cinacalcet (AMG 073) hydrochloride is a calcimimetic agent that acts as an allosteric activator of CaSR.
Cinacalcet (AMG 073) increases the concentration of cytoplasmic Ca(2+) in human embryonic kidney 293 cells expressing the human parathyroid CaR with EC50 of 51 nM.
Cinacalcet (AMG 073) decreases PTH secretion from cultured bovine parathyroid cells with IC50 of 28 nM.
Cinacalcet (AMG 073) is used for the treatment of tertiary hyperparathyroidism.

Physicochemical Properties

M.Wt	393.8729
Formula	C22H23ClF3N
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Naphthalenemethanamine, .alpha.-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-, hydrochloride (1:1), (.alpha.R)-

References

1. Nemeth EF, et al. J Pharmacol Exp Ther. 2004 Feb;308(2):627-35.

2. Lindberg JS, et al. Kidney Int. 2003 Jan;63(1):248-54.

3. Quarles LD, et al. J Am Soc Nephrol. 2003 Mar;14(3):575-83.

Cinacalcet hydrochloride (AMG 073 hydrochloride;AMG073 hydrochloride;AMG-073 hydrochloride;Cinacalcet)

Biological Activity

Physicochemical Properties

References

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